It is amply documented that major depressive disorder (MDD) is a prevalent, early age at onset, severe disorder with high rates of non-recovery, recurrence and chronicity. The COVID-19 pandemic has resulted in an increase in the number of persons across the USA and globally affected by MDD and related disorders (e.g., anxiety disorders). The foregoing composite of MDD alongside the national opioid epidemic and increased reporting of suicidality, especially amongst younger populations, has resulted in a consensus position that the USA and many other countries around the world are experiencing a mental health crisis.